On 7th of July 2007, Simon got married to Jocelyn Towne. Jocelyn Towne is also an American actress. She is also a well known producer and director. Their first child, Adeline Helberg was born in 2012 and their second child, Wilder Towne Helberg was born in the early 2014.
Simon was born and raised by the parents who are active in the film industry. He also got interested in acting at a young age and with the completion of his high school education, he joined New York University's Tisch School of the Arts. He took his acting training from Atlantic Theater Company. He began his comedy career as a comedy duo Derek & Simon. He began his acting career in 1999 and that was from the comedy movie, Mumford. Three years later, he appeared in the movie Van Wilder starring the role of Vernon. His breakthrough role came in 2007 after he began appearing in the television series, The Big Bang Theory where he starred the role of Howard Wolowitz. For his role in this series, he earned the salary of $100,000 per episode. His net worth is said to be in millions.