In the end of January 2002, she played the role of a lesbian mom on the sitcom Will & Grace. In February 2002, she revealed that she is lesbian indeed. She announced she is lesbian at the Ovarian Cancer Research benefit at Caroline's Comedy Club.
On 26th of February 2004, Rosie got married to Kelli Carpenter. Kelli Carpenter is a former Nickelodeon marketing executive. She is also an established producer and is famous for her work in the movie Pursuit of Equality. They had four children together. They annulled their married life in 2004.
In 2011, Rosie was seen having affairs with Michelle Rounds. Michelle Rounds is an executive-search consultant. At the end of 2011, she revealed that they are engaged. They finally got married on 9th of June 2012. They adopted a daughter named Dakota in the early 2013. This married life came to an end in March 2016. Her nationality is American and she is of white ethnicity.
Rosie was enrolled at Commack High School during her childhood days. There she was named homecoming queen, prom queen and so on. There she also induced her interest in standup comedy. She finally earned her high school graduation from there in 1980 and then she joined Dickinson College. After that she got transferred to Boston University. She began her career as a standup comedian while she was still in her high school. In 1979, she began touring as a stand-up comedian in clubs. She toured for the next five years. She got her rise in fame after she performed on Star Search. She made her acting debut in 1986 by starring the role of Maggie O'Brien in an American sitcom Gimme a Break!. In 1988, she came out as the host of the TV show Stand-Up Spotlight. She also served as the producer of this TV show. She made her feature film debut in 1992 by portraying the role of Doris Murphy in an American comedy-drama film A League of Their Own. In 1993, she appeared in the movies like Sleepless in Seattle, Another Stakeout and Fatal Instinct. She has also released several albums in her life. Her first album A Rosie Christmas was released in 1999 and this album was ranked 20 in US chart. In 2000, she released another album titled Another Rosie Christmas. She is also a great writer. In 2002, she published her first memoir Find Me. Her second book Celebrity Detox was published in 2007. She is said to have the net worth of 100 million dollars. She is now aged 54 years old.