In 1990 she started appeared in supporting guest roles on various TV series including; One Tree Hill (2003-04), Surface(2006), The Gates (2010) and much more. She also appeared in several short movies. After appearing in many TV series and short movies she was cast in 1999's big screen movie Atlantic Blue.
Thus, Ponzio won millions of hearts and appreciation for various movies like; Warm Springs (2005), My Fake Fiance (2009), Mary Matha (2013) and many others. In 2011, she appeared in a famous TV series Teen Wolf which and received a huge compliment for her role in the series and after the show's success, she got a chance to appeared in various shows. Currently, She is ready to Teases her fan with the new episode of Teen Wolf.
Moving towards her personal life, Melissa married Kenny Alfonso; an American actor. They got married after dating for several months.The couple is still together and blessed with one daughter; Jessy Alfonso.
Melissa earns a huge amount of money from her acting career. She works at several TV Network and earns a beautiful amount of salary. It has been estimated that her current Net worth is around $1 million.