George attended Warwick Senior High School where she developed her interest in dancing. At the age of seven, she began learning tap, jazz, modern dance and ballet. Her interest in dancing became her passion for artistic roller skating. She became national roller skating champion and won bronze medals in the National Championships in 1989 and 1990. Moreover, she also received a silver medal at the Junior World Championship in 1991.
In 1992, George began modeling and earned a name Western Australia's Teenage Model of the Year. When she was sixteen years old, she featured in a mock episode of the famous Australian TV show Home and Away along with her friend Cara Mitchinson.
George made her movie debut in an American-Australian neo-noir science fiction film Dark City, which was directed by Alex Proyas. The stars of this movie are Rufus Sewell, Kiefer Sutherland, Jennifer Connelly, and Richard O'Brien. The movie grossed $27.2 million at the box office against the budget of $27 million.
In 2005, George featured in hit American horror movie The Amityville Horror, which was directed by Andrew Douglas. The stars of this movie are Philip Baker Hall and Ryan Reynolds. The movie became a huge hit and grossed $108 million against the budget of $19 million.
Some hit movies of George are The Limey, Mulholland Drive, Music Within, 30 Days of Night, The Betrayed, Triangle, A Lonely Place to Die, Swinging with the Finkels, Between Us, Felony, and The Butterfly Tree.
Likewise, George also featured in some notable television series such as Roar, Murder Call, Silk Stalkings, Lost in Oz, Coupling, Charmed, L.A. Confidential, Two Twisted, Grey's Anatomy, Lie to Me, Hunted, The Good Wife, and Heartbeat.
George is of Caucasian ethnicity and holds an Australian nationality. George, 41, is currently single. She became a naturalized American citizen in 2008. She is the cousin of Taryn Fiebig, an opera singer. She married her longtime boyfriend Claudio Dabed, a Chilean furniture designer, and film director. However, she couldn't continue her married life with her husband Claudio and announced her divorce in 2011.
After divorcing her first husband, George started dating hip-hop mogul, Russell Simmons. The pair stayed in a relationship for a short time. She also had an affair with Jean David Blanc, a French entrepreneur, whom she met at the BAFTA after-party in 2011. She has two sons from her partner Jean namely Solal (born in 2015), and Raphael(born in 2014).
Most of Melissa income comes from her acting career. She has appeared in numerous movies and television series from which she must have collected a decent amount of salary. As per some online $5 million, her net worth of 2018 is calculated to be $5 million.