In 1999, Mekhi got married to Malinda Williams. Malinda Williams is an actress best known for starring the role of Tracy "Bird" Van Adams in the TV series Soul Food. As a husband and wife, they had a son named Omikaye Phife. They got divorced in 2003.
In 2007, Mekhi was spotted with Oni Souratha. Together they also had a son named Mekhi Thira Phifer Jr.. After they broke up, he began dating Reshelet Barnes. They finally got married on 30th of March 2013. They are still bonded into this married life. His nationality is American. He is of black ethnicity.
At a young age, Mekhi dreamed to be an actor. He was finally able to accomplish this dream during his early 20s. In 1995, he made his acting debut by appearing in an American police drama New York Undercover. That year he also made his feature film debut by portraying the role of Lewis Johns in the movie The Tuskegee Airmen. In the mid 1990s, he was seen in the movies like Clockers, High School High and Soul Food. He is critically acclaimed for starring the role of Jefferson in the movie A Lesson Before Dying and Dr. Greg Pratt on NBC's long-running medical drama ER. His net worth is -$1.3 Million and announced his bankruptcy in the early 2014.