On 31st of August 2003, Mayim got married to Michael Stone. Stone is a converted Judaism. Their wedding was held in a Victorian-themed ceremony. As a married couple, they have two children together. At the end of 2012, they announced their separation and they finally got divorced on 1st of May 2013.
Mayim is the graduate of North Hollywood High School but before that she also attended Walter Reed Junior High School. Though she got an offer to join Harvard and Yale, she preferred UCLA to stay close to her parents. She finally completed her Bachelor of Science degree in neuroscience and finally earned her PhD in neuroscience in 2007.
Mayim has been active in acting since 1987. That year, she appeared in the television series, neuroscience where she played the role of Ellie. The following year, she made her movie debut in Beaches. Her breakthrough role came in 1990 after she began starring the role of Blossom Russo in the TV series, Blossom. She is also well known for her role in the television series, The Big Bang Theory. For this role, she earned the salary of $60,000 per episode. Her net worth is said to be around $6 million.