Marisa first gained attention from the Perfect 10 magazine where she appeared nude. She was then repeatedly showcased on the cover of the magazine. She moved to high-profile mainstream work when the famous fashion photographer Mario Testino snapped some photos of her and approached her with a job offer for Vogue in 2001.
The 38-year-aged model got married to Jim Miller in 2000 and got divorced after 2 years in 2002. She again got married to Griffin Guess on April 15, 2006. She has two sons with her second husband Griffin.