Anderson began his professional career as a stand-up comedian on The Tonight Show. Following this, he appeared on the pilot episode of Perfect Strangers on ABC network where he cast as Lou Appleton along with Bronson Pinchot. When the show picked up, Anderson was replaced by Mark Linn-Baker as the producers didn't like the chemistry between Anderson and Pinchot.
In 1986, Anderson appeared in a small role in the singing telegram scene in Ferris Bueller's Day Off. A year later, Anderson featured in a comedy special on Showtime. Following this, Anderson appeared in the comedy movie, Coming to America, which was directed by Johan Landis.
Later in 1995, Anderson created and produced a Saturday morning animated series for Fox channel, Life With Louie. The story is based on the real life of Anderson's childhood together with ten siblings, a loving mother, and a loud, war-crazed father. This series became a hit and won the Daytime Emmy Awards for Outstanding Performer in an Animated Program.
On July 23, 2017, Anderson appeared on an episode of Celebrity Family Feud competing singer and actress Christina Milian. This makes him one of very few to have both hosted and been a contestant on the same game show.
Louie is the holder of American nationality and belongs to white ethnicity. Anderson married his school girlfriend in 1985. The couple couldn't continue their marriage for long and divorced after four weeks.
The popular actor and comedian, Louie has collected a tremendous amount of money from her acting career. As of 2017, his estimated net worth is $10 million.