After graduating from University, Nayyar starts doing Ads and Plays. He got good review from his role in Rajiv Joseph's 2006 play Huck & Holden. After making a Guest appearance on CBS drama NCIS, he got a role of astrophysicist Raj Koothrappali on The Big Bang Theory. Nayyar is Film, Television and Theatre actor and played different roles. According to the Forbes he is the third highest paid TV actor in 2015 with total earning $ twenty million US dollars.
Nayyar is a married man and living happily with his wife. He married Neha Kapur in December, 2011 and they do not have any children yet. Neha Kapur is a Miss India 2006. There is no rumor of him having any extra marital affairs.