On 28th of January 1933, James got married to his first wife Olivia Saunders. As a loving husband and wife, they were together for about half a decade and they called off this married life in the late 1930s. They got divorced in 1938.
Soon after James got divorced with Olivia Saunders, he was seen in Alma Mailman. They also tied their married life the same year. As a loving husband wife, they welcomed their first child together in 1940. They dissolved this married life in 1941.
In the early 1940s, he began his romantic love affairs with Mia Fritsch. They began loving together in Greenwich Village. After few years of love life, they finally got married in 1946. Together they welcomed three children named Julia and Andrea and John. His nationality was American and he was of white ethnicity.
When James was aged seven years old, his father died in an automobile accident. He was raised by his mother along with his sister. He received his formal education from School for Mountain Boys. There he became close with Episcopal priest Father James Harold Flye. Flye was the man behind his inspiration in writing. In 1924, he joined Knoxville High School and he studied there for about a year. At the end of 1920s, he joined Phillips Exeter Academy. There he worked as an editor of the Monthly and a president of The Lantern Club. He also attended Harvard University and he graduated from there in 1932. Soon after earning a degree from there, he joined Time Inc. where he worked as a reporter. He also worked as a writer for Fortune magazine for about half a decades from the early 1930s. His first volume of poetry was published in 1934 and it was published under the title Permit Me Voyage. In 1935, he published a poem Knoxville: Summer of 1915. In 1950s, he published several novels named The African Queen, Face to Face, The Night of the Hunter, A Death in the Family and many more. He is also known for his famous quotes.
James was a hard drinker and chain-smoker. In the early 1950s, he suffered his first heart stroke. On 16th of May 1955, while he was in New York City he got his second heart stroke. He was found dead in a taxi cab en route. He was aged 45 during the time of his death. His net worth was unknown.