By 1998, he had signed with Irv Gotti's record label Murder Inc (currently known as The Inc) and was featured with Amil on Jay-Z's chart-buster song "Can I Get A...” which earned him popularity and toured with the likes of Redman, DMX, Jay-Z and numerous others. He has worked closely with Ashanti, Mary J. Blige, Sum-41, and Lil- Mo and has been nominated for the esteemed Grammy Award three times in 2002 and once in 2003. His first No.1 track on the Billboard Hot 100 was "Always on Time" featuring R&B singer Ashanti from his album Pain is Love and other popular songs include “I’m Real (Murder Remix), “Between Me and You” and “Ain’t It Funny,” which reached the top 20 on U.S. Billboard Hot 100 chart.
Competition is apparent in the music industry and he has feuded with DMX, Lil Mo, Eminem, and Foxy Brown and has an ongoing rivalry with 50 Cent. Apart from music, he has exhibited his acting talent in movies with Vin Diesel in The Fast and the Furious (2001), Scary Movie 3 (2003) and Assault on Precinct 13 (2005), in which he co-starred with Ethan Hawke and Laurence Fishburne.
He was married to his high school sweetheart Aisha Murray in 2001 and has 3 kids - Brittney, Jeffrey Junior, and Jordan. His nationality is American and possesses the height of 5"7.
In 2013, he was sentenced to 28 months imprisonment for tax evasion and gun charges after he failed to pay taxes on more than $3 million in earnings form 2004 to 2006. He was released from the jail on May 7, 2013.
His first album Venni Vetti Vecci released in 1999 went on the hit the no. 1 spot on the Billboard 200 chart. The record sold 2 million copies worldwide and Ja Rule's earnings were estimated at $2.37 million.
He bought his California house in 2001 for $1,875,000.
His worth is evaluated at $7 million dollars as of 2018.