After graduating from Wimbledon School of Art in 2001, Chapman started her career as a costume designer. In 2003, She appeared in an American-HongKong martial arts comedy movie, Shanghai Knights. David Dobkin directed the movie and scripted by Alfred Gough and Miles Millar. Jackie Chan and Owen Wilson starred in this film.
Similarly, she has appeared in numerous movies and television series, including Match Point, The Business, Derailed, Factory Girl, The Nanny Diaries, Gossip Girl, and Project Runway: All Stars.
Chapman is a British by nationality and belongs to white ethnicity. She began dating her boyfriend Harvey Weinstein, a film producer in December 2004. The couple married on December 15, 2007, in Connecticut, the United States. The couple began spending their time in West Village townhouse, a seafront home in Westport, Connecticut, and a mansion in Los Angeles.