He got married to Mary Mercier on July 22, 1960. He met Mary Mercier while studying at the HB Studio in New York. But their married life didn’t go well and they started living apart. They got divorced in 1965. After that, he married to Mary Joan Schutz on October 27, 1967. They got divorce after seven years of marriage in 1974. He was suspected having love affair with actress Madeline Kanh before his second divorce. Then, he married to Gilda Radner on September 14, 1984, in the south of France. Their married life was going well but all of sudden Gilda Radner was found to have ovarian cancer in October 1986. She died on May 20, 1989. After that, he met Karen Webb and they got married on on September 8, 1991. They were together until his death from complications of Alzheimer’s disease on August 28, 2016 in Stamford, Connecticut at the age of 83.
He was American by his nationality and was of Russian American ethnicity. He adopted "Gene Wilder" for his professional name at the age of 26. His net worth was 20 million dollars.