After completion of his graduation, he moved to the State University of New York at Potsdam and dropped out from his college to pursue a career as a songwriter.
At the beginning of his career, Lorre wrote a hit single called "French Kissin' in the USA", which was recorded by Debbie Harry. After sometimes, he co-wrote the soundtrack to the 1987 television series Teenage Mutant Ninja Turtles, along with Dennis Challen Brown.
Later, Lorre created and co-produced an American sitcom Grace Under Fire that was aired on ABC, an American commercial broadcast television network. The cast members of this series are Brett Butler, Dave Thomas, Julie White, and Casey Sander.
After some year, Lorre again co-created, wrote, and produced American television series The Big Bang Theory, which was aired on CBS, an American English language commercial broadcast television network. The stars of this series are Johnny Galecki, Jim Parsons, Kaley Cuoco, and Simon Helberg.
Similarly, Lorre created, wrote, and produced numerous other television series that includes Frannie's Turn, Cybill, Dharma & Greg, Two and a Half Men, Mike & Molly, Mom, Disjointed, Young Sheldon, and The Kominsky Method.
Lorre is a white-American by ethnicity and nationality. He has been married two times in his life. He first married his girlfriend and business partner Paula Smith, in 1979. The couple is blessed with two children. He lived together with his wife and children for 13 years and later divorced his spouse in 1992.
After his divorce from his first wife, Lorre married Karen Witter, an actress, and former Playboy Playmate. However, the couple was unable to continue their marriage for a long time, and they got divorced in July 2010. Recently, in August 2017, Lorre got engaged to a behavioral health specialist named Arielle Mandelson.
Lorre earns a tremendous amount of money from his professional writing and producing career. He has written and produced numerous hit shows like Two and a Half Men, Grace Under Fire, The Big Bang Theory, Dharma and Greg, and Cybill, from which he must have collected a decent amount of salary. As per some online sources, his current net worth is estimated to be $800 million.