Cantrell is currently single and has neither been married nor has any children. In 2001 she was in a relationship with musician Jay Z. Cantrell has also dated Antonio Sabato Jr. in 2008 and Tomy Lee in 2003.
Cantrell began her singing career working on demons, a song or a group of a song recorded for a limited audience. Red Zone Entertainment divorced her in early 2001. She also did collaborations with a number of popular musicians including Usher, Jimmy Jam, Terry Lewis and Herbie Hancock.
In 2001, Cantrell released her debut album, So Blu. The album peaked number eight on Billboard 200 chart. So Blu's single Hit 'Em Up Style peaked number two on the U.S. Billboard Hot 100. The single became the number one most added record to radio in the country, breaking Elvis Presley's record for most played on all genres of radio.
Cantrell released her second album, Bittersweet in 2003. Bittersweet peaking at No. 37 on the Billboard 200. Two singles from the album, Breather and Make Me Wanna Scream were major hits of the album.
In 2007, Cantrell appeared in the musical stage play Gossip, Lies and Secrets, playing alongside Kenya Moore. In December 2016, Cantrell revealed to Fuse that she is up to a new album.
Her net worth is rumored to be around $5 million.